Pathogen and drug work together to fight fungal lung infection

Pathogens don’t always work against drug treatments. Sometimes, they can strengthen them, according to new research. Researchers have now looked at two pathogens that often occur at similar sites, particularly in cystic fibrosis and mechanically ventilated patients: Candida albicans and Pseudomonas aeruginosa. The researchers investigated the effectiveness of an antifungal drug, fluconazole, with both pathogens. The results showed that P. aeruginosa works with fluconazole to eliminate drug tolerance and clear the C. albicans infection. The bacteria also enhance the drug’s ability against a second pathogenic Candida species that tends to be more resistant to the drug.