Researchers have clarified the relationship between the intracellular receptor PQBP1 and the structural protein Tau, which is dysregulated in neurodegenerative diseases such as Alzheimer’s disease. Tau was found to interact with PQBP1 in immune cells of the brain, which led to activation of the inflammatory cGAS-STING pathway. PQBP1 may represent a potential target for the development of therapeutics to treat Tau-mediated neurodegenerative diseases.