‘Super-spreader’ events and extensive person-to-person contact propelled an outbreak of hantavirus pulmonary syndrome in a small village in Argentina from 2018-2019, according to new research. An international scientific team reports the genetic, clinical, and epidemiologic features of the outbreak caused by the Andes virus, a member of the hantavirus family. Their analysis could aid in managing outbreaks of other viral diseases with similar transmission patterns, including COVID-19.